Detailed Information On Available EAE models
EAE Model | Species and Strain | Features and Use |
---|---|---|
Acute | Guinea pig: Dunkin Hartley Rat: Lewis |
Short-term resolving or non-resolving disease with perivascular CNS lesions. Useful for establishing initial prophylactic or therapeutic efficacy. |
Acute adoptive | Rat: Lewis | In vivo and in vitro system useful for determining mechanisms of compound efficacy. Several stages available for drug intervention. |
Chronic | Mouse: SJL/J, C57BL/6 | Chronic neurological disease without definite remission but features demyelination and axonal disruption. Allows extended dosing regime to treat chronicity of disease. |
Chronic relapsing | Mouse: Biozzi | The definitive model of relapsing-remitting EAE including episodes of paralysis and chronic spasticity with demyelination and axonal degeneration. Facility for dosing during acute, remission and relapse phases. |
Key to images
- Plate 1: Perivascular lesions in spinal cord from acute EAE-diseased rat
- Plate 2: Diffuse lesions in mouse spinal cord during the acute phase of chronic relapsing-remitting EAE
- Plate 3: Myelinated and demyelinated axons in mouse spinal cord during the relapse phase of chronic relapsing-remitting EAE