Solupharm Limited

Pre-clinical MS Research using EAE models

A Selection of Recent Publications

Bolton C, Smith PA
The influence and impact of ageing and immunosenescence (ISC) on adaptive immunity during multiple sclerosis (MS) and the animal counterpart experimental autoimmune encephalomyelitis (EAE).
Ageing Res Rev. 2018; 41:64-81

Bolton C, Smith P
Defining and Regulating Acute Inflammatory Lesion Formation during the Pathogenesis of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.
CNS Neurol Disord Drug Targets. 2015;14(7):915-35

Bolton C, Gates J, Giovannoni G
Serum levels of 25-hydroxy vitamin D in normal Biozzi and C57BL/6 mice and during the course of chronic relapsing experimental autoimmune encephalomeyelitis (CR EAE).
Inflamm Res 2013Jul;62(7):659-67

Bolton C, Wood EG, Ayoub SS
N-Methyl-D-Aspartate (NMDA) receptor involvement in central nervous system prostaglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE).
Fundam Clin Pharmacol. 2013 Oct:27(5):535-43

Ayoub SS, Wood EG, Hassan SU, Bolton C
Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomeyelitis (EAE).
Inflamm Res. 2011 Oct;60(10):919-28